Structure of PDB 7ndo Chain B

Receptor sequence
>7ndoB (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
LTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADRELVHMIN
WAKKVPGFVDLSRHDQVHLLESAWLEILMIGLVWRSMDHPGKLLFAPDLL
LDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILLNSGVY
TSSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKSKNVVPSYDLLLEMLDAHR
3D structure
PDB7ndo A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAL B L346 T347 A350 D351 E353 W383 L387 F404 I424 H524 V533 P535 L37 T38 A41 D42 E44 W74 L78 F95 I115 H213 V222 P224 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:7ndo, PDBe:7ndo, PDBj:7ndo
PDBsum7ndo
PubMed34006920
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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