Structure of PDB 7na0 Chain B

Receptor sequence

>7na0B (length=978) Species: 243231 (Geobacter sulfurreducens PCA)

NSELNTKIVNRGKEFFGSISGEKPSLFNKGAWMGKAMDWSMQNEQFKIQM
FRFVDVFPSLTTSKLLTEHIREYFGNEQDMPAFMNKVLTSNIEEMARQFI
VGETTKEAVKNLEKLRKDGFAAVVDVLGEATLSEEEAEVYTNTYLELLEA
LKKEQGSWKGLPGKGGDPGLDWGHAPKVNIAVKPTWLFCLANPQDFEGSV
VAILDRMRRIFKKVMELNGFLCIDMESYRHKEIILEVFRRLKLEYRDYPH
LGIVLQAYLKDNDKDLDDLLAWAKEHKVQISVRLVKGAYWDYETVKAKQN
DWEVPVWTIKAESDAAYERQARKILENHQICHFACASHNIRTISAVMEMA
RELNVPEDRYEFQVLYGMAEPVRKGILKVAGRIRLYAPYGNMVPGMGYLV
RRLLENTANESFLRQSFAEDAQIERLLEDPAVTVERERAARARKGLGGLP
PFNNEAMVDFTRADHRAAFPKHIAQVRTQLGKTYPLFINGKEVRTNDLIP
TVNPNKPSEVLGQICQAGTTEVGDAIAAAKAAFPAWRDTDPRTRAEYLLK
AAQAARKRLFELSAWQVLEIGKQWDQAYADVTEAIDFLEYYAREMIRLGQ
PQRVGHAPGELNHYFYEPKGVAAVIAPWNFPLAISMGMASAAIVTGNCVV
FKPSGITSIIGWHLVELFREAGLPEGVFNFTPGRGSVMGDYLVDHPDISL
IAFTGSMETGLRIIERAAKVHPGQANVKKIISEMGGKNAIIIDDDADLDE
AVPHVLYSAFGFQGQKCSACSRVIVLDAVYDKFIERLVSMAKATKVGPSE
DPANYMGAVADDKAMKSIKEYAEIGKREGHVLYESPVPAGEGYFVPMTII
GGIKPEHRIAQEEIFGPVLAVMRAKDFDQAIEWANSTQFALTGGIFSRSP
EHLAKARREFRVGNLYINRNNTGALVERQPFGGARMSGVGTKAGGPDYLL
HFMDPRVVTENTMRRGFAPIEEDDDWVD

3D structure

• PDB: 7na0 Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA).
• Chain: B
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	D244 M245 V274 Q276 R303 V305 K306 G307 A308 Y309 W310 W327 T328 I329 K330 S333 A356 S357 H358 N359 Q383 L385 Y406 E425 S431 F432	D224 M225 V254 Q256 R283 V285 K286 G287 A288 Y289 W290 W307 T308 I309 K310 S313 A336 S337 H338 N339 Q363 L365 Y386 E405 S411 F412

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
• GO:0004657 proline dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006562 proline catabolic process
• GO:0010133 proline catabolic process to glutamate

Cellular Component

• GO:0005737 cytoplasm
• GO:0009898 cytoplasmic side of plasma membrane

External links

• PDB: RCSB:7na0, PDBe:7na0, PDBj:7na0
• PDBsum: 7na0
• PubMed: 34506758
• UniProt: Q746X3