Structure of PDB 7n9g Chain B

Receptor sequence
>7n9gB (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
DKWEMERTDITMKHKLGGYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL
KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE
VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL
SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIAT
YGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRP
SFAEIHQAFETMFQ
3D structure
PDB7n9g Imatinib can act as an Allosteric Activator of Abl Kinase.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STI B A356 L359 L360 A452 E481 G482 P484 V487 M515 F516 Q517 A103 L106 L107 A199 E228 G229 P231 V234 M262 F263 Q264
BS02 1N1 B L267 A288 K290 E305 M309 I332 T334 F336 M337 T338 G340 L389 A399 L16 A35 K37 E52 M56 I79 T81 F83 M84 T85 G87 L136 A146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n9g, PDBe:7n9g, PDBj:7n9g
PDBsum7n9g
PubMed34774565
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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