Structure of PDB 7n93 Chain B

Receptor sequence
>7n93B (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA
KDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL
EREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKL
TDFGLCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENR
KKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQA
HPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDNQVFL
GFEYVAPSV
3D structure
PDB7n93 Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
ChainB
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SK B G98 K99 G100 G103 K104 V105 A121 K123 L172 E179 E222 M225 T235 D236 G14 K15 G16 G19 K20 V21 A37 K39 L88 E95 E138 M141 T151 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7n93, PDBe:7n93, PDBj:7n93
PDBsum7n93
PubMed34596404
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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