Structure of PDB 7n6q Chain B

Receptor sequence
>7n6qB (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
KQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFILLEFD
LLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGGLGCALLAAHAVV
LCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGILRAAPS
FSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGR
LCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFA
EMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGAR
ARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMAWNV
LMWTMLFLGQGIQVSLYCQEWYARR
3D structure
PDB7n6q Structure of PPPA bound human ACAT2
ChainB
Resolution3.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.26: sterol O-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7T8 B Y391 S430 A431 F438 M449 Q485 Q488 Y492 Y274 S313 A314 F321 M332 Q360 Q363 Y367 BindingDB: IC50=179nM
BS02 CLR B F160 F234 E235 A311 C312 W362 F56 F124 E125 A194 C195 W245
BS03 CLR B F120 Y124 F127 I128 C307 L352 F356 W382 F21 Y25 F28 I29 C190 L235 F239 W265
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0015485 cholesterol binding
GO:0016746 acyltransferase activity
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0010878 cholesterol storage
GO:0030299 intestinal cholesterol absorption
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034383 low-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005903 brush border
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n6q, PDBe:7n6q, PDBj:7n6q
PDBsum7n6q
PubMed
UniProtO75908|SOAT2_HUMAN Sterol O-acyltransferase 2 (Gene Name=SOAT2)

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