Structure of PDB 7n3r Chain B

Receptor sequence
>7n3rB (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
KYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEF
DLVFTSVLNRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQ
MALNHGEEQVRLWRRSYNVTPPPIEESHPYYQEIYNDRRYKVCDVPLDQL
PRSESLKDVLERLLPYWNERIAPEVLRGKTILISAHGNSSRALLKHLEGI
SDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEAI
3D structure
PDB7n3r Molecular insight into 2-phosphoglycolate activation of the phosphatase activity of bisphosphoglycerate mutase.
ChainB
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.4.2.11: phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
5.4.2.4: bisphosphoglycerate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA B C23 S24 E89 C21 S22 E87
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004082 bisphosphoglycerate mutase activity
GO:0004619 phosphoglycerate mutase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular phosphotransferase activity
GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0006753 nucleoside phosphate metabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0015671 oxygen transport
GO:0033554 cellular response to stress
GO:0042832 defense response to protozoan
GO:0048821 erythrocyte development
GO:0060856 establishment of blood-brain barrier
GO:0150076 neuroinflammatory response
GO:1901136 carbohydrate derivative catabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7n3r, PDBe:7n3r, PDBj:7n3r
PDBsum7n3r
PubMed35362470
UniProtP07738|PMGE_HUMAN Bisphosphoglycerate mutase (Gene Name=BPGM)

[Back to BioLiP]