Structure of PDB 7n0b Chain B

Receptor sequence
>7n0bB (length=512) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
ENVTGLFKDCSKVITGLHPTQAPTHLSVDTKFKTEGLCVDIPGIPKDMTY
RRLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATREAV
GTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGDQFKHLIP
LMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKI
GPERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTG
NLQSNHDLYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGD
ELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFY
DAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRF
DTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSP
CESYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVY
KQFDTYNLWNTF
3D structure
PDB7n0b Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B K9 H95 N104 K8 H94 N103
BS02 rna B E2 D90 E92 G93 F146 W186 G251 N252 E1 D89 E91 G92 F145 W185 G250 N251
BS03 CA B D90 E92 D273 D89 E91 D272
BS04 CA B D90 A187 E191 D89 A186 E190
BS05 ZN B C210 C226 H229 C209 C225 H228
BS06 ZN B H257 C261 H264 C279 H256 C260 H263 C278
BS07 ZN B C452 C477 C484 H487 C451 C466 C473 H476
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7n0b, PDBe:7n0b, PDBj:7n0b
PDBsum7n0b
PubMed34315827
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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