Structure of PDB 7mzb Chain B

Receptor sequence
>7mzbB (length=536) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRP
GFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVE
VADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASS
GKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKN
SVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCL
YMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGI
QYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVF
SLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFST
AVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAY
VILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCM
RKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTW
3D structure
PDB7mzb Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
ChainB
Resolution3.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6EU B Y511 S512 L515 M547 T550 N551 Y554 R557 E570 Y318 S319 L322 M354 T357 N358 Y361 R364 E377 BindingDB: Ki=0.13nM,IC50=180nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mzb, PDBe:7mzb, PDBj:7mzb
PDBsum7mzb
PubMed34496225
UniProtO35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

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