Structure of PDB 7mx3 Chain B

Receptor sequence
>7mx3B (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
PAPLVSIEELENQELVGKFGTVFRAQHRKWGYDVAVKIVNSKAISREVKA
MASLDNEFVLRLEGVIKVNWDQDPALVTKFMENGSLSGLLQSQAPRPWPL
LCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTT
LGYLAPEASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMV
ENNMNAAVSTVKDFLSQLR
3D structure
PDB7mx3 Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
ChainB
Resolution3.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOV B V35 A48 K50 M64 L73 L92 T94 M97 G100 L149 V22 A35 K37 M51 L60 L76 T78 M81 G84 L133
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7mx3, PDBe:7mx3, PDBj:7mx3
PDBsum7mx3
PubMed34811356
UniProtQ9Y572|RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (Gene Name=RIPK3)

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