Structure of PDB 7mx1 Chain B

Receptor sequence
>7mx1B (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAI
ILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYG
CCKELASRLRYARTMVDKLLSS
3D structure
PDB7mx1 Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.
ChainB
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W414 V415 D416 L490 L491 R516 H538 K540 W43 V44 D45 L119 L120 R145 H167 K169
BS02 ZOY B Y417 Y421 L478 Y481 F482 Y485 Y46 Y50 L107 Y110 F111 Y114
External links
PDB RCSB:7mx1, PDBe:7mx1, PDBj:7mx1
PDBsum7mx1
PubMed34346472
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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