Structure of PDB 7mtq Chain B

Receptor sequence
>7mtqB (length=744) Species: 9606 (Homo sapiens) [Search protein sequence]
KVLTLEGDLVLGGLFPVHQKPAEDCGPVNEHRGIQRLEAMLFALDRINRD
PHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLPTAITGVIGGSYSDV
SIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAE
ILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSR
AAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGW
GALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFRE
FWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHR
ALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFG
DGIGRYNIFTYLRAGGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPAS
RCSEPLQNEVKSVQPEVCCWLCIPQPYERLDEFTCADGLGPNASLTGCFE
LPQEYIRWGDWAVGPVTIACLGALATLFVLGVFVRHNTVVKASGRELCYI
LLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIA
RIFFISPASQVAICLALISGQLLIVVAWLVVEAPGTTAPEVVTLRCNHRD
ASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLA
FLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILF
3D structure
PDB7mtq G-protein activation by a metabotropic glutamate receptor.
ChainB
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z99 B R57 Y144 S145 A166 T168 Y216 R32 Y97 S98 A119 T121 Y169 BindingDB: Ki=3.13nM,IC50=200nM,EC50=>100000nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mtq, PDBe:7mtq, PDBj:7mtq
PDBsum7mtq
PubMed34194039
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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