Structure of PDB 7mon Chain B

Receptor sequence
>7monB (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
KLWPSGAPAPLVSIEELENQELVGTVFRAQHRKWGYDVAVKIVNSKAISR
EVKAMASLDNEFVLRLEGVIEKVNWDPKPALVTKFMENGSLSGLLQSQAP
RPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADF
GLSGEPGGTLGYLAPELFVNKASTASDVYSFGILMWAVLAGREVELPTEP
SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSF
QECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSS
3D structure
PDB7mon Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
ChainB
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZL1 B V27 A48 K50 V52 I57 E60 M64 L92 T94 F96 M97 G100 L149 A159 D160 F161 V23 A39 K41 V43 I48 E51 M55 L81 T83 F85 M86 G89 L138 A148 D149 F150 BindingDB: IC50=2.9nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7mon, PDBe:7mon, PDBj:7mon
PDBsum7mon
PubMed34811356
UniProtQ9Y572|RIPK3_HUMAN Receptor-interacting serine/threonine-protein kinase 3 (Gene Name=RIPK3)

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