Structure of PDB 7meu Chain B

Receptor sequence
>7meuB (length=184) Species: 9606 (Homo sapiens) [Search protein sequence]
YIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSS
NLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLET
LLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVY
KERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
3D structure
PDB7meu A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
ChainB
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP B W56 M101 W102 E103 R157 K162 K206 W23 M68 W69 E70 R124 K129 K173 BindingDB: Ki=28nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7meu, PDBe:7meu, PDBj:7meu
PDBsum7meu
PubMed33892272
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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