Structure of PDB 7mbp Chain B

Receptor sequence
>7mbpB (length=996) Species: 7955 (Danio rerio) [Search protein sequence]
RLGDIDFTGVSRTRGKFVRVTSSTDPAEIYQILTKQWGLAPPHLVVALMG
GDEVAQLKPWLRDTLRKGLVKAAQSTGAWILTSGLRFGITKNLGQAVRDH
SLASTSPKVRVVAIGIAPWNMIQNRDLLLSAKPDHPATYPTEDLPYGAVY
SLDCNHSHFILVDEDPKRPGATGEMRVKMLKHISLQRTGYGGTGSIEIPV
LCLLVHGEPRILQKMYKNIQNSIPWLILAGSGGVADILVTLMDRGCWDAD
IVQELLINTFPDGLHSTEITSWTKLIQRILDHGHLLTVHDPEQDSELDTV
ILKALVKACKSQSQEAQDFLDELKLAVAWNRVDIAKSEIFSGDVQWSAQD
LEEVMMEALVNDKPDFVRLFVDNGVNIKQFLTYGRLQELYCSVSEKNLLH
TLLLKKNQERQAQLKFRFTFHEVSKVLKDFLDDTCKGFYQKLNLPDMDRR
CEHPWRDLFLWAILQNRQEMANYFWAMGPEAVAAALVGCKIMKEMAHLAT
EAESARSMKNAKYEQFAMDLFSECYSNSEDRAYSLLVRKTCCWSKATVLN
IATLAEAKCFFAHDGVQALLTKVWWGAMRTDTSISRLVLTFFIPPLVWTS
LIKFNPESATFIRVVLRRWNRFWSAPVTVFMGNVIMYFAFLILFSYVLLL
DFRPPPPYGPSAAEIILYFWVFTLVLEEIRQSFFTDEDMSILKKMKLYVE
DNWNKCDMVAISLFVVGLSCRMAMSTYEAGRTVLALDFMVFTLRLIHIFA
IHKQLGPKIIIVERMIKDVFFFLFFLSVWLIAYGVTTQALLHPNDPRIDW
VFRRALYRPYLHIFGQIPLEEIDAAKMPDDNCTTDVQEIILGTLPPCPNI
YANWLVILLLVIYLLVTNVLLLNLLIAMFSYTFQVVQENADIFWKFQRYN
LIVEYHSRPALAPPFIIISHITQALLSFIKDLLERELPSGLDQKLMTWET
VQKENYLAKLEHEHRESSGERLRYTSSKVQTLLRMVGGFKDQEKRM
3D structure
PDB7mbp Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YUY B D889 W890 D799 W800
BS02 YUY B A914 A915 M917 W944 I947 A824 A825 M827 W854 I857
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mbp, PDBe:7mbp, PDBj:7mbp
PDBsum7mbp
PubMed34168372
UniProtS5UH55

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