Structure of PDB 7m96 Chain B

Receptor sequence
>7m96B (length=166) Species: 9913 (Bos taurus) [Search protein sequence]
TLGARRGLEWFLGFYFLSHIPITLLMDLQGVLPRDLYPVELRNLQQWYIE
EFKDPLLQTPPAWFKSFLFCELVFQLPFFPIAAYAFFKGGCKWIRTPAII
YSVHTMTTLIPILSTLLLDDFSKASHFRGQGPKTFQERLFLISVYIPYFL
IPLILLLFMVRNPYYK
3D structure
PDB7m96 Structures of the sigma 2 receptor enable docking for bioactive ligand discovery.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YTD B D29 E73 V146 Y147 Y150 D27 E71 V144 Y145 Y148
Gene Ontology
Molecular Function
GO:0008142 oxysterol binding
GO:0015485 cholesterol binding
Biological Process
GO:0032377 regulation of intracellular lipid transport
GO:0032383 regulation of intracellular cholesterol transport
GO:0042632 cholesterol homeostasis
GO:0090303 positive regulation of wound healing
GO:0140077 positive regulation of lipoprotein transport
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031965 nuclear membrane

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Cellular Component
External links
PDB RCSB:7m96, PDBe:7m96, PDBj:7m96
PDBsum7m96
PubMed34880501
UniProtQ3MHW7|SGMR2_BOVIN Sigma intracellular receptor 2 (Gene Name=TMEM97)

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