Structure of PDB 7m6o Chain B

Receptor sequence
>7m6oB (length=357) Species: 7955 (Danio rerio) [Search protein sequence]
MPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMD
YRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGAN
FHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQLE
SFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKF
TCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGI
TTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFI
ARQHKELLRTVEEMRKLFISRAKRIDTVSRVAFPLVFLIFNIFYWITYKI
IRSEDIH
3D structure
PDB7m6o Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
ChainB
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY B F87 R89 L141 S153 F56 R58 L110 S122
BS02 TCI B A417 F418 V421 A332 F333 V336
BS03 GLY B F183 F231 F152 F200
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0022824 transmitter-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:7m6o, PDBe:7m6o, PDBj:7m6o
PDBsum7m6o
PubMed35982060
UniProtO93430|GLRA1_DANRE Glycine receptor subunit alphaZ1 (Gene Name=glra1)

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