Structure of PDB 7m4m Chain B

Receptor sequence
>7m4mB (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
ELVRCPSCSFPALLDSDVKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEE
LAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMC
YLCRVSINGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKE
AEEEQKRKNGFKRIGPPL
3D structure
PDB7m4m Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
ChainB
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C605 C623 C628 C5 C23 C28
BS02 ZN B C633 H643 C648 C33 H43 C48
BS03 ZN B C675 C678 C693 C695 C75 C78 C93 C95
BS04 ZN B C700 H712 C730 C100 H112 C130
BS05 ZN B C714 H716 C724 C727 C114 H116 C124 C127
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7m4m, PDBe:7m4m, PDBj:7m4m
PDBsum7m4m
PubMed34998453
UniProtQ9NWF9|RN216_HUMAN E3 ubiquitin-protein ligase RNF216 (Gene Name=RNF216)

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