Structure of PDB 7m3j Chain B

Receptor sequence

>7m3jB (length=785) Species: 9606 (Homo sapiens)

AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMI
FAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL
IPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFL
RTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
ICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIV
RRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFL
KKVHPRKSVHNGFAKEFWEETFNCHLQESVETPYIDYTHLRISYNVYLAV
YSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMG
EQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFIN
EEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYS
DETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGI
FLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQD
WTCRLRQPAFGISFVLCISCILVKTNRVLLLNLQFLLVFLCTFMQIVICV
IWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFF
AFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCS

3D structure

• PDB: 7m3j Asymmetric activation of the calcium-sensing receptor homodimer.
• Chain: B
• Resolution: 4.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YP1	B	Q681 F684 F814 W818 F821 Y825 E837 I841	Q607 F610 F724 W728 F731 Y735 E747 I751	BindingDB: IC50=43nM

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7m3j, PDBe:7m3j, PDBj:7m3j
• PDBsum: 7m3j
• PubMed: 34194040
• UniProt: P41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)