Structure of PDB 7m0m Chain B

Receptor sequence
>7m0mB (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEP
DDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI
YQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVR
LADFGISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLG
ITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIK
VTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB7m0m Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
ChainB
Resolution1.93 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D135 K137 A139 N140 D153 A162 T173
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YK1 B L23 G25 G26 V31 A44 M91 E92 F93 C94 G95 G97 D101 L144 D155 L21 G23 G24 V29 A42 M89 E90 F91 C92 G93 G95 D99 L142 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7m0m, PDBe:7m0m, PDBj:7m0m
PDBsum7m0m
PubMed33859804
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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