Structure of PDB 7m0l Chain B

Receptor sequence
>7m0lB (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
DIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDV
STLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT
GSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADF
GISAQIGAELARRLEFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAI
ELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLT
KSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL
3D structure
PDB7m0l Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
ChainB
Resolution2.43 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D131 K133 A135 N136 D149 A158 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YK4 B L23 G24 Y28 V31 A44 M91 E92 C94 G95 G97 D101 L144 F156 L17 G18 Y22 V25 A38 M85 E86 C88 G89 G91 D95 L138 F150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7m0l, PDBe:7m0l, PDBj:7m0l
PDBsum7m0l
PubMed33859804
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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