Structure of PDB 7ltx Chain B

Receptor sequence

>7ltxB (length=293) Species: 9606 (Homo sapiens)

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP
YDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFREL
IIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM

3D structure

• PDB: 7ltx Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ANP	B	G719 S720 G721 V726 A743 K745 M790 M793 C797 D837 R841 N842 L844	G20 S21 G22 V27 A44 K46 M91 M94 C98 D138 R142 N143 L145
BS02	MG	B	N842 D855	N143 D156
BS03	YFA	B	V726 A743 I744 K745 E758 I759 A763 M766 L777 L788 M790 D855 F856	V27 A44 I45 K46 E59 I60 A64 M67 L78 L89 M91 D156 F157

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:7ltx, PDBe:7ltx, PDBj:7ltx
• PDBsum: 7ltx
• PubMed: 35378251
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)