Structure of PDB 7lou Chain B

Receptor sequence
>7louB (length=540) Species: 1496 (Clostridioides difficile) [Search protein sequence]
SLVNRKQLEKMANVRFRTQEDEYVAILDALEEYHNMSENTVVEKYLKLKD
INSLTDIYIDTYKKSGRNKALKKFKEYLVTEVLELKNNNLTPVEKNLHFV
WIGGQINDTAINYINQWKDVNSDYNVNVFYDSNAFLINTLKKTVVESAIN
DTLESFRENLNDPRFDYNKFFRKRMEIIYDKQKNFINYYKAQREENPELI
IDDIVKTYLSNEYSKEIDELNTYIEESLNKITQNSGNDVRNFEEFKNGES
FNLYEQELVERWNLAAASDILRISALKEIGGMYLDVDMLPGIQPDLFESI
EKPSSVTVDFWEMTKLEAIMKYKEYIPEYTSEHFDMLDEEVQSSFESVLA
SKSDKSEIFSSLGDMEASPLEVKIAFNSKGIINQGLISVKDSYCSNLIVK
QIENRYKILNNSLNPAISEDNDFNTTTNTFIDSIMAEANADNGRFMMELG
KYLRVGFFPDVKTTINLSGPEAYAAAYQDLLMFKEGSMNIHLIEADLRNF
EISKTNISQSTEQEMASLWSFDDARAKAQFEEYKRNYFEG
3D structure
PDB7lou Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.
ChainB
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP B V101 W102 I103 N139 L265 S269 D286 D288 S518 L519 W520 V100 W101 I102 N138 L264 S268 D285 D287 S517 L518 W519
BS02 IFM B D270 R273 D286 N384 T465 D269 R272 D285 N383 T464
BS03 MN B D288 E515 D287 E514
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7lou, PDBe:7lou, PDBj:7lou
PDBsum7lou
PubMed34725358
UniProtP18177|TCDB_CLODI Toxin B (Gene Name=tcdB)

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