Structure of PDB 7lo0 Chain B

Receptor sequence
>7lo0B (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]
AKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESE
EYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTY
RGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHI
NWE
3D structure
PDB7lo0 Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
ChainB
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B A48 E49 E51 D54 D88 V94 R108 G110 Y111 Y112 R145 A47 E48 E50 D53 D87 V93 R107 G109 Y110 Y111 R144
BS02 peptide B N114 N138 L140 S142 N143 R145 N113 N137 L139 S141 N142 R144
BS03 peptide B F28 D58 S59 V60 L61 H70 M71 V73 F27 D57 S58 V59 L60 H69 M70 V72
Gene Ontology
Biological Process
GO:0006325 chromatin organization
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7lo0, PDBe:7lo0, PDBj:7lo0
PDBsum7lo0
PubMed35136069
UniProtQ9Y294|ASF1A_HUMAN Histone chaperone ASF1A (Gene Name=ASF1A)

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