Structure of PDB 7lje Chain B

Receptor sequence
>7ljeB (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
KFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVK
PGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCP
PPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW
ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDI
FKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQDLSQKLYATMEKHK
EVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDRHLEFS
SLRRAQWSTGCMLVELHTQSQDRF
3D structure
PDB7lje Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.
ChainB
Resolution2.607 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y2P B F1374 L1398 D1399 S1400 Y1414 P1440 G1443 D1444 Y1446 Q1455 K1456 I1457 P1458 W1466 Y1467 F88 L112 D113 S114 Y128 P154 G157 D158 Y160 Q169 K170 I171 P172 W180 Y181
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lje, PDBe:7lje, PDBj:7lje
PDBsum7lje
PubMed33631370
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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