Structure of PDB 7lhb Chain B

Receptor sequence
>7lhbB (length=136) Species: 9606 (Homo sapiens) [Search protein sequence]
YDNREIVMKYIHYKLSQKGYEWEVVHLTLRQAGDDFSRRYRRDFAEMSSQ
LHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSP
LVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB7lhb Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
ChainB
Resolution2.068 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XZD B A100 D103 F104 Y108 M115 E136 L137 N143 W144 G145 R146 V148 E152 F153 Y202 A32 D35 F36 Y40 M47 E68 L69 N75 W76 G77 R78 V80 E84 F85 Y134
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7lhb, PDBe:7lhb, PDBj:7lhb
PDBsum7lhb
PubMed33785651
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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