Structure of PDB 7lh7 Chain B

Receptor sequence
>7lh7B (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
SNRELVVDFLSYKLSQKGYMAAVKQALREAGDEFELRYRRAFSDLTSQLH
ITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKKMQVLV
SRIAAWMATYLNDHLEPWIQENGGWATFVELYGNN
3D structure
PDB7lh7 Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor
ChainB
Resolution1.409 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XZM B E96 F97 Y101 F105 S106 D107 L108 T109 L130 N136 W137 G138 R139 V141 A142 S145 F146 A149 F191 Y195 N197 N198 E33 F34 Y38 F42 S43 D44 L45 T46 L67 N73 W74 G75 R76 V78 A79 S82 F83 A86 F128 Y132 N134 N135 BindingDB: Ki=0.1nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7lh7, PDBe:7lh7, PDBj:7lh7
PDBsum7lh7
PubMed
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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