Structure of PDB 7lg8 Chain B

Receptor sequence
>7lg8B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT
SPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDY
VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV
KITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDNFYRALM
3D structure
PDB7lg8 Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
ChainB
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNS B A743 K745 I759 M766 L777 L788 M790 D855 F856 L858 A42 K44 I58 M65 L76 L87 M89 D154 F155 L157
BS02 8RC B L718 A743 M790 L792 M793 P794 F795 G796 C797 D800 E804 L17 A42 M89 L91 M92 P93 F94 G95 C96 D99 E103
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lg8, PDBe:7lg8, PDBj:7lg8
PDBsum7lg8
PubMed35534503
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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