Structure of PDB 7lfv Chain B

Receptor sequence
>7lfvB (length=312) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search protein sequence]
VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHE
GKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGL
TSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALI
LAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTG
VEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEY
KLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVT
DVFYKETSYTTT
3D structure
PDB7lfv A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease.
ChainB
Resolution2.23 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B C112 L163 G164 D165 P248 P249 Y265 Y269 Q270 C271 G272 H273 C110 L161 G162 D163 P246 P247 Y263 Y267 Q268 C269 G270 H271
BS02 ZN B C190 C193 C227 C188 C191 C225
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lfv, PDBe:7lfv, PDBj:7lfv
PDBsum7lfv
PubMed34547223
UniProtP0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)

[Back to BioLiP]