Structure of PDB 7les Chain B

Receptor sequence
>7lesB (length=448) Species: 1257118 (Acanthamoeba castellanii str. Neff) [Search protein sequence]
KGKLPPVVSSLIPFVGSGLSFAGGPLQYTTDAYKKYGDIFTMKVFGQRLT
FLVGPDAHVPFFSQGDAELSQDEPYQFSVPIFGPNVVYGADLAHRNQQLK
FIAASLSTKALQSYVPLIVKEAEDFFAKWDKSGTVDIRDALAELIILTAS
RCLMGKEIRENLFTEVAKLYQTLDEGLLPISVFFPYLPIPAHKRRDEARL
AMVRMFKKIIDERRANPEVKHNDCLQVFMDARYRGEEQALNDEEITGLMI
ALLFAGQHTSSVTGSWTGLLLFEANNKKKFLPGVLEEQEEIRKEFGDELT
MEALNKMDKLHRCVKEALRMYPPLLFVMRKVIKPFSYKDYYVPEGDTVFV
SPALSMRVEEVFPNADQYNPERFVEEDKQAQKYRFVGFGAGRHGCMGENF
AYLQIKTIWSVLLRNFDIELVGELPKPDYTAMVVGPAHPCLLRYTRKH
3D structure
PDB7les Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51.
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B Y114 A294 G295 T298 P362 V366 R368 G426 F427 H432 C434 M435 G436 Y75 A255 G256 T259 P323 V327 R329 G387 F388 H393 C395 M396 G397
BS02 IMD B A294 L363 A255 L324
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008168 methyltransferase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7les, PDBe:7les, PDBj:7les
PDBsum7les
PubMed35730528
UniProtL8GJB3

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