Structure of PDB 7lc3 Chain B

Receptor sequence

>7lc3B (length=673) Species: 83333 (Escherichia coli K-12)

EPTLVVQALKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMASGAMP
GNALFSAAISGWLWITVLFANFAEALAEGRSKAQANSLKGVKKTAFARKL
REPKYGAAADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAIT
GEAAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEG
AQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALL
VCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKT
GTITLGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILAKQR
FNLRERDVQSLHATFVPFTAQSRMSGINIDNRMIRKGSVDAIRRHVEANG
GHFPTDVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQ
LRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAE
GRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLI
EVVHIGKQMLMTRGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNIMC
LHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGL
GGLLVPFIGIKVIDLLLTVCGLV

3D structure

• PDB: 7lc3 Structural basis for potassium transport in prokaryotes by KdpFABC.
• Chain: B
• Resolution: 3.23 Å

Enzymatic activity

• Enzyme Commision number: 7.2.2.6: P-type K(+) transporter.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	W31 P34 F37 I38 I226 T229 I230 L233 L234 A237	W22 P25 F28 I29 I217 T220 I221 L224 L225 A228
BS02	9Y0	B	S647 R651 L654 W655 G658 L662	S638 R642 L645 W646 G649 L653
BS03	MG	B	D518 G519	D509 G510
BS04	ACP	B	D307 T309 R317 D344 F377 R382 K395 G396 S397 L431 G472 D473	D298 T300 R308 D335 F368 R373 K386 G387 S388 L422 G463 D464

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0005215 transporter activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0008556 P-type potassium transmembrane transporter activity
• GO:0015662 P-type ion transporter activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006813 potassium ion transport
• GO:0071805 potassium ion transmembrane transport
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0031004 potassium ion-transporting ATPase complex
• GO:1903103 potassium:proton antiporter complex

External links

• PDB: RCSB:7lc3, PDBe:7lc3, PDBj:7lc3
• PDBsum: 7lc3
• PubMed: 34272288
• UniProt: P03960|KDPB_ECOLI Potassium-transporting ATPase ATP-binding subunit (Gene Name=kdpB)