Structure of PDB 7lc2 Chain B

Receptor sequence
>7lc2B (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGREEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKH
3D structure
PDB7lc2 RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B G13 G15 K16 S17 A18 F28 D30 Y32 T35 G60 K117 S145 A146 K147 G13 G15 K16 S17 A18 F28 D30 Y32 T35 G60 K117 S145 A146 K147
BS02 MG B S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lc2, PDBe:7lc2, PDBj:7lc2
PDBsum7lc2
PubMed34380736
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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