Structure of PDB 7la4 Chain B

Receptor sequence
>7la4B (length=377) Species: 9606 (Homo sapiens) [Search protein sequence]
FPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVR
QVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGA
FVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNE
EVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTH
IALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNIN
LIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKV
ELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRG
CPQEKEKSFTIKPVGFKDSLIVQVTFD
3D structure
PDB7la4 Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S121 E220 S66 E165
BS02 CA B S123 D126 D127 S68 D71 D72
BS03 CA B D158 N215 D217 P219 E220 D103 N160 D162 P164 E165
External links
PDB RCSB:7la4, PDBe:7la4, PDBj:7la4
PDBsum7la4
PubMed33760023
UniProtP05106|ITB3_HUMAN Integrin beta-3 (Gene Name=ITGB3)

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