Structure of PDB 7l9y Chain B

Receptor sequence
>7l9yB (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
QNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKK
KTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTY
FAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQ
NPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB7l9y Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XRM B H1682 G1683 A1706 Y1714 S1722 Y1727 H68 G69 A92 Y100 S108 Y113 BindingDB: IC50=<1000nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7l9y, PDBe:7l9y, PDBj:7l9y
PDBsum7l9y
PubMed33838082
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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