Structure of PDB 7l6t Chain B

Receptor sequence
>7l6tB (length=114) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
FAVDAAKAYKDYLASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESF
GGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCANDPVGFTLKNTVCT
VCGMWKGYGCSCDQ
3D structure
PDB7l6t Mn 2+ coordinates Cap-0-RNA to align substrates for efficient 2'- O -methyl transfer by SARS-CoV-2 nsp16.
ChainB
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C4327 C4330 H4336 C4343 C56 C59 H65 C72
BS02 ZN B C4370 C4373 C4381 C4383 C99 C102 C110 C112
BS03 BDF B T4292 N4293 C4294 T21 N22 C23
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008270 zinc ion binding
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7l6t, PDBe:7l6t, PDBj:7l6t
PDBsum7l6t
PubMed34131072
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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