Structure of PDB 7l6c Chain B

Receptor sequence
>7l6cB (length=268) Species: 561007 (Mycobacteroides abscessus ATCC 19977) [Search protein sequence]
AGLLEGKRILVTGIITDSSIAFHIAKVAQEQGAELVLTGFDRLRLIERIT
QRLPKPAPLLELDVQNEEHLGSLAGRISEVIGEGNKLDGVVHSIGFMPQS
GMGVNPFFDAPFADVSKGFHISAFSYSSLAKAVLPVMNRGGSIVGMDFDP
TRAMPAYNWMTVAKSALESVNRFVAREAGKVGVRSNLVAAGPIRTLAMSA
IVGGALGDEAGQQMQLLEEGWDQRAPIGWDMKDPTPVAKTVCALLSDWLP
ATTGDIIFADGGAHTQLL
3D structure
PDB7l6c Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.
ChainB
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G14 I16 S20 I21 F41 D64 V65 S94 I95 M147 D148 F149 K165 P193 I194 G13 I15 S19 I20 F40 D63 V64 S93 I94 M146 D147 F148 K164 P192 I193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7l6c, PDBe:7l6c, PDBj:7l6c
PDBsum7l6c
PubMed36107992
UniProtB1MC30

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