Structure of PDB 7l4m Chain B

Receptor sequence

>7l4mB (length=350) Species: 3702 (Arabidopsis thaliana)

PIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWET
ISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDA
FPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKHV
QRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTER
FKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIK
MKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEK
YGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMR

3D structure

• PDB: 7l4m Substrate deformation regulates DRM2-mediated DNA methylation in plants.
• Chain: B
• Resolution: 2.805 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	L278 N280 S400 A401 R406 S470 R471 T472 G592 R595	L4 N6 S126 A127 R132 S196 R197 T198 G318 R321
BS02	dna	B	E312 V314 R347 R349 N392 C393 L395 T396 C397 G479 N480 S585 C587 N588 A591 G592 G593 N594	E38 V40 R73 R75 N118 C119 L121 T122 C123 G205 N206 S311 C313 N314 A317 G318 G319 N320
BS03	SAH	B	N480 F482 F508 T509 E532 I533 D559 I560 L608	N206 F208 F234 T235 E258 I259 D285 I286 L334

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:7l4m, PDBe:7l4m, PDBj:7l4m
• PDBsum: 7l4m
• PubMed: 34078593
• UniProt: Q9M548|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)