Structure of PDB 7l4f Chain B

Receptor sequence

>7l4fB (length=350) Species: 3702 (Arabidopsis thaliana)

PIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWET
ISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDA
FPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKHV
QRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTER
FKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIK
MKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEK
YGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMR

3D structure

• PDB: 7l4f Substrate deformation regulates DRM2-mediated DNA methylation in plants.
• Chain: B
• Resolution: 2.55 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	N280 K319 S400 A401 Q402 R406 R471 T472 G592 N594 R595	N6 K45 S126 A127 Q128 R132 R197 T198 G318 N320 R321
BS02	dna	B	E312 V314 R347 R349 N392 C393 T396 C397 N480 S585 P586 C587 N588 A591 G592 G593 R595	E38 V40 R73 R75 N118 C119 T122 C123 N206 S311 P312 C313 N314 A317 G318 G319 R321
BS03	SAH	B	N480 S481 F482 F508 T509 E532 I533 D559 I560 L608	N206 S207 F208 F234 T235 E258 I259 D285 I286 L334

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:7l4f, PDBe:7l4f, PDBj:7l4f
• PDBsum: 7l4f
• PubMed: 34078593
• UniProt: Q9M548|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)