Structure of PDB 7l3q Chain B

Receptor sequence

>7l3qB (length=629) Species: 246410 (Coccidioides immitis RS)

LPVVVEAHQVDTFDVPGVFYENHPHEPHLSGMNEYNQLYQQSINDPDTFW
ARMARDLITFEKDFDKTHIGTLEGGDNAWFVGGRLNASFNCVDRHAMRDP
NKVAIIYEADEPGHGRSITYAELLKEVSRLAWVMKSQGVRKGDTVAIYLP
MIPEAIFALLACARIGAIHSVVFAGFSSDSLRDRTLDARSKFIITTDEGK
RGGKVIGTKKIVDEALKQCPDVTNCLVFKRTGADVPWTKGRDLWWHEEVD
KYPNYLPAESMDSEDPLFLLYTSGSTGKPKGVMHTTAGYLVGAAATGKYV
FDIHPADRFFCGGDVGWITGHTYVVYAPLLLGCTTVVFESTPAYPNFSRY
WDVIEKHKVTQFYVAPTALRLLKRAGDHHINHEMKDLRILGSVGEPIAAE
VWKWYHEVVGKRQAHIVDTYWQTETGSHVITPLGGITPTKPGSASLPFFG
IDPVILDPVTGAEIPGNDVEGILAFRKPWPSMARTVWGDHKRYMDTYLNV
YKGFYFTGDGAGRDHEGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHHC
VAEAAVVGVPDPLTGQAVHAFVALKSGNDNREQLQKELIMQVRKSIGPFA
APKVVFVIDMRRILRKILIIDTFHEWKKA

3D structure

• PDB: 7l3q Crystal Structure of Acetyl-CoA synthetase in complex with adenosine-5'-methylphosphate and Co-enzyme A from Coccidioides immitis RS
• Chain: B
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T281 T432 E433 N539 R544
• Catalytic site (residue number reindexed from 1): T272 T423 E424 N530 R535
• Enzyme Commision number: 6.2.1.1: acetate--CoA ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COA	B	F182 G184 R210 G322 Y372 A374 V402 S541 G542 R602 F608	F173 G175 R201 G313 Y363 A365 V393 S532 G533 R593 F599
BS02	XM7	B	G403 E404 P405 T428 Y429 W430 Q431 T432 D518 I530 R533 R544	G394 E395 P396 T419 Y420 W421 Q422 T423 D509 I521 R524 R535

Gene Ontology

Molecular Function

• GO:0003987 acetate-CoA ligase activity
• GO:0005524 ATP binding
• GO:0016208 AMP binding
• GO:0016874 ligase activity

Biological Process

• GO:0006085 acetyl-CoA biosynthetic process
• GO:0019427 acetyl-CoA biosynthetic process from acetate

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7l3q, PDBe:7l3q, PDBj:7l3q
• PDBsum: 7l3q
• UniProt: J3KJC6