Structure of PDB 7l26 Chain B

Receptor sequence
>7l26B (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
IFNRDPRDHYDLLQRLGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKE
ILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSEL
QISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFSAQIGA
TLAIGTPYWMAPEVAAVALKGCYNELCDIWSLGITAIELAELQPPLFDVH
PLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKML
SHQLVSQPGLNRGLILDLLDKLKNP
3D structure
PDB7l26 Identification of Potent Reverse Indazole Inhibitors for HPK1.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D125 K127 A129 N130 D143 A150 T156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHM B L23 V31 K46 M91 C94 G97 L144 D155 L16 V19 K34 M79 C82 G85 L132 D143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7l26, PDBe:7l26, PDBj:7l26
PDBsum7l26
PubMed33738073
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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