Structure of PDB 7l24 Chain B

Receptor sequence
>7l24B (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
DIFNRDPRDHYDLLQRLGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK
EILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSE
LQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQ
IGTPYWMAPEVAAVALKGCYNELCDIWSLGITAIELAELQPPLFDVHPLR
VLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQ
LVSQPGLNRGLILDLLDKLKN
3D structure
PDB7l24 Identification of Potent Reverse Indazole Inhibitors for HPK1.
ChainB
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 T175
Catalytic site (residue number reindexed from 1) D126 K128 A130 N131 D144 T153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHV B L23 V31 A44 M91 F93 C94 G97 D101 N142 L144 L17 V20 A33 M80 F82 C83 G86 D90 N131 L133
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7l24, PDBe:7l24, PDBj:7l24
PDBsum7l24
PubMed33738073
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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