Structure of PDB 7l00 Chain B

Receptor sequence
>7l00B (length=311) Species: 1496 (Clostridioides difficile) [Search protein sequence]
SHMNKICKILNIKYPVIQGGMAWVATASLASAVSNAGGLGIIAAGNAPKE
AIKKEIVECKKLTDKPFGVNVMLMSPFVDDIIDLIIEEKVQVITTGAGNP
AKYMDRLKEAGTKVIPVVPTIALAQRMEKLGATAVIAEGTEGGGHIGELT
TMVLVPQVADAVNIPVIAAGGIVDGRGIAASFALGASAVQVGTRFICSEE
CSVHSNYKNLVLKAKDRDAIVTGRSTGHPVRTLKNKLSKEFLKMEQNGAT
PEELDKKGTGALRFATVDGDIEKGSFMAGQSAAMVKEITPCKEIIEAMVN
QAREIMPAIEL
3D structure
PDB7l00 Crystal Structure of C. difficile Enoyl-Acyl Carrier Protein Reductase (FabK) in Complex with an Inhibitor
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.12.16: nitronate monooxygenase.
1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B G17 G18 M19 A20 N68 E136 G140 G141 G168 G169 Q188 G190 T191 M275 S279 G19 G20 M21 A22 N70 E138 G142 G143 G170 G171 Q190 G192 T193 M277 S281
BS02 XCJ B A20 G43 N44 M70 G94 A95 G96 V115 P117 E136 H143 M275 A22 G45 N46 M72 G96 A97 G98 V117 P119 E138 H145 M277
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0004497 monooxygenase activity
GO:0018580 nitronate monooxygenase activity
GO:0051213 dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:7l00, PDBe:7l00, PDBj:7l00
PDBsum7l00
PubMed
UniProtA0A031WIF2

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