Structure of PDB 7kzz Chain B

Receptor sequence

>7kzzB (length=281) Species: 70863 (Shewanella oneidensis)

VKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFI
AIRYAIVPADHDHRYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNP
SPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDL
FLNAAVLLALVLSQYGWWWADGLFAVLIACYIGQQAFDLGYRSIQALLDR
ELDEDTRQRIKLIAKEDPRVLGLHDLRTRQAGKTVFIQFHLELDGNLSLN
EAHSITDTTGLRVKAAFEDAEVIIHQDPVQV

3D structure

• PDB: 7kzz Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP.
• Chain: B
• Resolution: 3.42 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H234 H250 D287	H224 H240 D277
BS02	ZN	B	D70 H73 H77	D60 H63 H67
BS03	ZN	B	D47 D51 H155 D159	D37 D41 H145 D149
BS04	ZN	B	H263 D267	H253 D257
BS05	ZN	B	H285 D287	H275 D277

Gene Ontology

Molecular Function

• GO:0008324 monoatomic cation transmembrane transporter activity
• GO:0015086 cadmium ion transmembrane transporter activity
• GO:0015093 ferrous iron transmembrane transporter activity
• GO:0015341 zinc efflux active transmembrane transporter activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0006826 iron ion transport
• GO:0006829 zinc ion transport
• GO:0006882 intracellular zinc ion homeostasis
• GO:0034220 monoatomic ion transmembrane transport
• GO:0034755 iron ion transmembrane transport
• GO:0055085 transmembrane transport
• GO:0070574 cadmium ion transmembrane transport
• GO:0071577 zinc ion transmembrane transport
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7kzz, PDBe:7kzz, PDBj:7kzz
• PDBsum: 7kzz
• PubMed: 34254979
• UniProt: Q8E919|FIEF_SHEON Cation-efflux pump FieF (Gene Name=fieF)