Structure of PDB 7kz4 Chain B

Receptor sequence
>7kz4B (length=378) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
HHHAENLESYNPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDT
SNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTIT
PRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDK
LLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGL
RDNQEAGKLKNIILSVKEEIDNLEKFLWFNTTKKKPLVFVKLAPDLNQEQ
KKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKF
ICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKS
AVQIKRELNHLLYQRGYYNLKEAIGRKH
3D structure
PDB7kz4 Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G248 N274 F278 S345 N347 T348 K429 N458
Catalytic site (residue number reindexed from 1) G97 N123 F127 S194 N196 T197 K241 N270
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XC7 B L172 C184 H185 L187 F188 I263 R265 Y528 V532 G535 L21 C33 H34 L36 F37 I112 R114 Y340 V344 G347
BS02 FMN B A225 G226 K229 T249 N274 N342 K429 S477 G478 S505 G506 G507 Y528 S529 A74 G75 K78 T98 N123 N191 K241 S289 G290 S317 G318 G319 Y340 S341
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7kz4, PDBe:7kz4, PDBj:7kz4
PDBsum7kz4
PubMed33876936
UniProtQ08210|PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (Gene Name=PFF0160c)

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