Structure of PDB 7kxw Chain B

Receptor sequence
>7kxwB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IPATITERYKVGRTIFAVVKECVERSTAREYALKIIKKSKGKEHMIQNEV
SILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERD
ASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA
TIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPF
RGSQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQ
VLEHPWVND
3D structure
PDB7kxw Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.
ChainB
Resolution3.002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XBD B V449 M465 E466 V468 G471 N516 L518 G532 V62 M78 E79 V81 G84 N129 L131 G145 BindingDB: IC50=17nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kxw, PDBe:7kxw, PDBj:7kxw
PDBsum7kxw
PubMed34545159
UniProtO15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)

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