Structure of PDB 7kx8 Chain B

Receptor sequence
>7kx8B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
FQIPATITERYKVGRTIGFAVVKECVERSTAREYALKIIKKSKCRGKEHM
IQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAKYTERD
ASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHKSLKLGDFGLATIVD
GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGEV
LFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPW
V
3D structure
PDB7kx8 Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8J B I396 V404 A417 M465 E466 V468 K469 G471 L518 I17 V22 A35 M83 E84 V86 K87 G89 L131 BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7kx8, PDBe:7kx8, PDBj:7kx8
PDBsum7kx8
PubMed34545159
UniProtO15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)

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