Structure of PDB 7kpy Chain B

Receptor sequence
>7kpyB (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNP
MDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLA
EVFEQEIDPVMQSLG
3D structure
PDB7kpy Development of Dimethylisoxazole-Attached Imidazo[1,2- a ]pyridines as Potent and Selective CBP/P300 Inhibitors.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WU1 B L1109 P1110 F1111 V1115 L1120 N1168 R1173 V1174 F1177 L27 P28 F29 V33 L38 N86 R91 V92 F95
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7kpy, PDBe:7kpy, PDBj:7kpy
PDBsum7kpy
PubMed33872011
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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