Structure of PDB 7kpr Chain B

Receptor sequence
>7kprB (length=391) Species: 9606 (Homo sapiens) [Search protein sequence]
SDLPLRFPYGRPEFLGLSQDEVECSADHIARPILILKETRRLPWATGYAE
VINAGKSTHNEDQASCEVLTVKVSCHYWSLFDGHAGSGAAVVASRLLQHH
ITEQLQDIVDILKNIPHECLVIGALESAFKEMDLQIERERSSYNISGGCT
ALIVICLLGKLYVANAGASRAIIIRNGEIIPMSSEFTPETERQRLQYLAF
MQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDEDLKF
PLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYD
LSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLA
AQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGN
3D structure
PDB7kpr Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.
ChainB
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D151 D437 D498 D82 D317 D378
BS02 MG B D151 G152 D82 G83
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
GO:0005515 protein binding
GO:0017018 myosin phosphatase activity
GO:0042802 identical protein binding
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0045202 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kpr, PDBe:7kpr, PDBj:7kpr
PDBsum7kpr
PubMed34580980
UniProtQ9ULR3|PPM1H_HUMAN Protein phosphatase 1H (Gene Name=PPM1H)

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