Structure of PDB 7knf Chain B

Receptor sequence

>7knfB (length=505) Species: 6239 (Caenorhabditis elegans)

VANKVCLIVIDGWGVSEDPYGNAILNAQTPVMDKLCSGNWAQIEAHGLHV
GLPEGLMGNSEVGHLNIGAGRVIYQDIVRINLAVKNNKFVTNESLVDACD
RAKNGNGRLHLAGLVSDGGVHSHIDHMFALVKAIKELGVPELYLHFYGDG
RDTSPNSGVGFLEQTLEFLEKTTGYGKLATVVGRYYAMDRDNRWERINVA
YEAMIGGVGETSDEAGVVEVVRKRYAADETDEFLKPIILQGEKGRVQNDD
TIIFFDYRADRMREISAAMGMKLAHPSNLQVYGMTQYKAEFPFKSLFPPA
SNKNVLAEWLAEQKVSQFHCAETEKYAHVTFFFNGGLEKQFEGEERCLVP
SPKVATYDLQPEMSAAGVADKMIEQLEAGTHPFIMCNFAPPDMVGHTGVY
EAAVKACEATDIAIGRIYEATQKHGYSLMVTADHGNAEKMKAPDGGKHTA
HTCYRVPLTLSHPGFKFVDPADRHPALCDVAPTVLAIMGLPQPAEMTGVS
IVQKI

3D structure

• PDB: 7knf Structure-activity relationship of ipglycermide binding to phosphoglycerate mutases.
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 5.4.2.12: phosphoglycerate mutase (2,3-diphosphoglycerate-independent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	L82 N85 E87 V88 Q101 D102 R284 R289 T319 P333 F366 G369 H485	L56 N59 E61 V62 Q75 D76 R258 R263 T285 P299 F332 G335 H451
BS02	ZN	B	S86 H485	S60 H451
BS03	ZN	B	D37 S86 D467 H468	D11 S60 D433 H434
BS04	ZN	B	D426 H430 H485	D392 H396 H451

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004619 phosphoglycerate mutase activity
• GO:0016853 isomerase activity
• GO:0030145 manganese ion binding
• GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006007 glucose catabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7knf, PDBe:7knf, PDBj:7knf
• PDBsum: 7knf
• PubMed: 33812994
• UniProt: G5EFZ1|GPMI_CAEEL 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (Gene Name=ipgm-1)