Structure of PDB 7klz Chain B

Receptor sequence
>7klzB (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
HMVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGL
DEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFV
QGKDWGFKKFIRRGFLLDEANGLLPDDKLTLFCEVSVVQ
3D structure
PDB7klz SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y123 D130 W131 G132 F133 Y97 D104 W105 G106 F107
External links
PDB RCSB:7klz, PDBe:7klz, PDBj:7klz
PDBsum7klz
PubMed34599168
UniProtO43791|SPOP_HUMAN Speckle-type POZ protein (Gene Name=SPOP)

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