Structure of PDB 7kl8 Chain B

Receptor sequence
>7kl8B (length=140) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
EYAPSPLDWSREQADTYMKSGGTEGTQLQGKPVILLTTVGAKTGKLRKTP
LMRVEHDGQYAIVASLGGAPKNPVWYHNVVKNPRVELQDGTVTGDYDARE
VFGDEKAIWWQRAVAVWPDYASYQTKTDRQIPVFVLTPVR
3D structure
PDB7kl8 Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F 420 H 2 -dependent reduction.
ChainB
Resolution2.469 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.98.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F42 B S15 Q18 G45 K47 T48 R52 P55 L56 M57 V68 S70 L71 P78 V79 W80 Y125 S10 Q13 G40 K42 T43 R47 P50 L51 M52 V63 S65 L66 P73 V74 W75 Y120
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0070967 coenzyme F420 binding
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Cellular Component
External links
PDB RCSB:7kl8, PDBe:7kl8, PDBj:7kl8
PDBsum7kl8
PubMed34161270
UniProtP9WP11|FQR58_MYCTU F420H(2)-dependent quinone reductase Rv1558 (Gene Name=Rv1558)

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